分子量: 249.11
cas no.:1349734-00-4
结构式:
规格:95%
用途:基础原料、有机中间体、医药中间体
合成路线如下:
(1,1'-bis(diphenylphosphino)ferrocene)palladium(ii) dichloride; potassium acetate; 1,4-dioxane;
reactants are commercially availlable.
chan, katrina, us2013/53362, a1, (2013) [0999] to a suspension of ? 5-bromo-1-ethylpyridin-2(1h)-one (250 mg, 1.23 mmol) in ? 1,4-dioxane (15 ml), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi( ? 1,3,2-dioxaborolane (346.4 mg, 1.35 mmol), ? 1 ,1?-bis(diphenyl phosphino)ferrocene]dichloropalladium(ii) (100 mg, 0.12 mmol) and ? potassium ace tate (301.4 mg, 3.08 mmol) were added. the reaction mixture was stirred at reflux for 3 h. the resu lting mixture was concentrated in vacuo, and the residue was purified by column chromatography on silica gel (10-101)'0 pe-ae) to afford ? 1-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyr idin-2(1h)-one
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