eschenmoser盐,二甲基亚甲基碘化铵是一个很强的二甲氨基甲基化试剂,用于制备
rch2n(ch3)2一类化合物。烯醇化物、烯醇硅醚及更酸性的酮都可有效的进行二甲氨基甲基化用于mannich反应。
机理
反应实例
参考文献
1. schreiber, j.; maag, h.;hashimoto, n.; eschenmoser, a. angew. chem. int. ed. 1971,
10, 330–331.
2. kleinman, e. f. dimethylmethyleneammoniumiodide and chloride. in encyclopedia
of reagents fororganic synthesis (ed: paquette, l.a.) 2004, wileynew york. (review).
3. nicolaou, k. c.; reddy, k.r.; skokotas, g.; sato, f.; xiao, x. y.; hwang, c. k. j.
am. chem. soc. 1993, 115, 3558–3575.
4. lidia kupczyk-subotkowska,l.; shine, h. j. j. labelled compd. radiopharm. 1993,
33, 301-304.
5. saczewski, j.; gdaniec, m. tetrahedronlett. 2007, 48, 7624–7627.
6. hong, a.-w.; cheng, t.-h.;raghukumar, v.; sha, c.-k. j. org. chem. 2008, 73,
7580–7585.
7. cesario, c.; miller, m. j. org.lett. 2009, 11, 449–452.
8. crimmins, m. t.; zuccarello,j. l.; ellis, j. m.; mcdougall p. j.; haile, p. a.; parrish,
j. d.; emmitte, k. a. org. lett. 2009, 11,489-492.
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