名称：2-甲基-4-羟甲基噻唑
英文名称：(2-methyl-1,3-thiazol-4-yl)methanol
分子式：c5h7nos
分子量: 129.18018
cas no.：76632-23-0
结构式：
外观：黄色液体
规格：95%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
lithium aluminium tetrahydride; tetrahydrofuran; diethyl ether;
reactants are commercially availlable.
novartis pharma gmbh, wo2005/77932, a2, (2005) 2-methyl-thiazole-4-carboxylic acid ethyl ester (966 mg, 5.64 mmol) is dissolved in 5 mi of diethylether and cooled to-78°c. a 1 m solution of lithium aluminium hydride in thf (16.9 ml, 16.9 mmol) is added dropwise and the mixture is sirred for 3.5h at-78°c. the mixture is quenched at this temperature with a saturated solution of sodium sulphate and is allowed to warm up to room temperature, followed by extraction with ether and evaporation. yield : 670 mg (92percent). ms (es i) : 130.0 [m-h]-, 1h-nmr (cdc13) : b (ppm) 7.20 (s, 1h), 5.27 (dd, 1h), 4.50 (d, 2h), 2.62 (s, 3h).