产品推荐：2,4-米乐m6平台

2020/10/15 10:06:16
by admin

规格：95%

外观：棕色固体

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

1,4-dioxane;

reactants are commercially availlable.
schering corporation, wo2008/54702, a1, (2008) example 32preparation of intermediate compound 32aa mixture of 3-bromopyruvic acid (16.37 g, 98.05 mmol) in anhydrous dioxane (90 ml_) was treated with ethyl thioamidooxalate (13.08 g, 98.22 mmol) for 1.2 h at 50 0c, and was then concentrated at 50 0c to yield a dry yellow solid. the crude product was dissolved in saturated sodium bicarbonate (150 ml) and water (150 ml). this solution was extracte d with ethyl acetate (6 x 400 ml). the aqueous epo layer was then acidified to ph 2 with concentrated aqueous hci (21 ml_), resulting in the formation of a heavy precipitate. this suspen sion was extracted with ethyl acetate (5 x 500 ml_). these extracts were pooled, dried with sodium sulfate, filtered, concentrated, and dried for about 15 hours under vacuum to yield compound 32a as a red-brown solid (14.36 g, 73percent yield) which was used without further purification.