别名：2-甲基-4h-3,1-苯并恶嗪-4-酮
英文名称：2-methyl-3,1-benzoxaza-4-one
分子式：c9h7no2
cas no.：525-76-8
分子量：161.16
结构式：
规格：95%
外观：淡黄色至棕色固体
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
methanol;
reactants are commercially availlable.
easy and efficient strategy was undertaken to synthesize the target quinazoline schiff?s base which involves the following three steps. in the first synthesis step, a warm solution of methyl anthranil ate reacts with acetic anhydride in 20ml methanol, results in the formation of a cyclic compound 2-methyl-4h-benzo [d] [1,3] oxazin-4-one. the second step involves the reaction between 2-methyl-4h-ben zo [d] [1,3] oxazin-4-one and hydrazine hydrate in 20ml hot methanol to afford 3-amino-2-methylquinazoline-4(3h)-one [18]. finally, in the third step the simple condensation reaction between 3-amino-2 -methyl quinazoline-4-one and 2-hydroxy-1-naphthaldehyde results in the formation of the schiff?s base (e)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3h)-one hnmamq as present ed in supplementary file fig. s1. the progress of the reaction was continuously monitored by the aid of thin layer chromatography (tlc) on a silica gel-g coated aluminum plates (merck) and spots were visualized by exposing the dry plates to iodine vapors.