别名：2-氨基-5-溴噻唑氢溴酸盐
英文名称：2-amino-5-bromothiazole monohydrobromide
分子式：c3h4br2n2s
cas no.：61296-22-8
分子量：259.95
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
bromine; chloroform; alcl3, aluminium chloride
reactants are commercially availlable.
wyeth, us2007/4786, a1, (2007) example 112; preparation of 2-amino-5-(3bromophenyl)-5-[5-(2-ethyl-[1,3]dioxolan-2-yl)-thiophen-3-yl]-3-methyl-3,5-dihydro-imidazol-4-one; step a); a stirred suspension of aluminum trichloride (6.27 g, 47.1 mmol) in chloroform at room tempe rature was treated sequentially with 2-(1-propionyl)thiophene (3.00 g, 21.4 mmol) and bromine (3.60 g, 22.4 mmol), stirred for 17 h, poured into iced water and diluted with methylene chloride. the phases were separated and the aqueous phase was extracted with methylene chloride. the extracts and the organic phase were combined, washed with water and brine, dried over sodium sulfate and concentrated to afford 2 (5.51 g, 117percent) as a dark orange oil: 1h nmr (300 mhz, cdcl3) delta 7.59 (d, j=1.1 hz, 1h), 7.51 (d, j=1.1 hz, 1h), 2.91 (q, j=7.3 hz, 2h), 1.23 (t, j=7.3 hz, 3h); esi ms m/z 219 [c7h7bros h] .