吡咯用从氯仿和naoh反应而来的二氯卡宾处理发生环丙烷化,接着重排生成3-氯吡啶。
反应机理
反应实例
参考文献
1. ciamician, g. l.; dennsted, m. ber. 1881, 14,1153.
2. wynberg, h. chem. rev. 1960,60, 169-184. (review).
3. wynberg, h. and meijer, e.w. org. react. 1982, 28, 1-36. (review).
4. parham, w. e.; davenport, r.w.; biasotti, j. b. j. org. chem. 1970, 35, 3775-3779.
5. král, v.; gale, p. a.;anzenbacher, p. jr.; k. jursíková; lynch, v.; sessler, j. l. chem. comm. 1998, 9-10.
6. pflum, d. a. ciamician–dennstedrearrangement. in name reactions in heterocyclic chemistry; li, j. j.,ed.; wiley: hoboken, nj, 2005, pp 350-354. (review).
feel free to call us on
025-85998075
drop us a line anytime at
,
and we’ll get back
soon.
come visit us at 2 qiande road, life science high tech zone, jiang ning district, nanjing, jiangsu province, china