名称：2-溴-1-乙基-3-甲基苯
英文名称：1-bromo-2-ethyl-6-methylbenzene
分子式：c9h11br
分子量: 199.09
cas no.：65232-55-5
结构式：
规格：97%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
hydrogen bromide; copper(i) bromide; sodium nitrite; water;
reactants are commercially availlable.
glaxo group limited, wo2006/100119, a1, (2006) description 3; - l-bromo-2-ethyl-6-methylbenzene2-ethyl-6-methylaniline (35 g, 0.259 mol) was added to cooled concentrated hydrobromic acid (120 ml). the stirred suspension was maintained between 5°c and 9°c while a solution of sodium nitrite (18.2 g, 0.264 mol) in water (40 ml) was added. a solutio n of copper (i) bromide (20.4 g, 0.142 mol) in concentrated hydrobromic acid (28 ml) was added and t he reaction mixture was allowed to rise to room temperature. the mixture was stirred at room tempera ture for 1 hour and then 30 minutes at 40°c. after cooling to room temperature hexane was added. the organic layer was washed with water, dried (mgso4) and evaporated. purification by chromatography on silica gel (hexane) gave the title compound. 1h nmr (cdcl3) delta 1.22 (t, 3h), 2.42 (s, 3h), 2.78 (q, 2h), 7.04-7.14 (m, 3h).