n-酰基邻氨基联苯用pocl3在硝基苯中回流发生闭环脱水而环合成菲啶。
反应机理
反应实例
morgan-walls反应是pictet-hubert反应的变异，后者的菲啶是由n-酰基邻氨基联苯用zncl2加热到250—300℃发生闭环脱水而环合成的
反应实例
参考文献
1. (a) pictet, a.; hubert, a. ber.1896, 29, 1182??1189. (b) morgan, c. t.;walls, l. p. j. chem. soc. 1931, 2447?2456. (c)morgan, c. t.; walls, l. p. j. chem. soc. 1932, 2225?2231.
2. gilman, h.; eisch, j. j.am. chem. soc. 1957, 79, 4423?4426.
3. hollingsworth, b. l.;petrow, v. j. chem. soc. 1961, 3664?3667.
4. fodor, g.; nagubandi, s. tetrahedron1980, 36, 1279?1300.
5. atwell, g. j.; baguley, b.c.; denny, w. a. j. med. chem. 1988, 31, 774?779.
6. peytou, v.; condom, r.;patino, n.; guedj, r.; aubertin, a.-m.; gelus, n.; bailly, c.;
terreux, r.; cabrol-bass, d. j.med. chem. 1999, 42, 4042?4043.
7. holsworth, d. d. pictet–hubertreaction. in name reactions in heterocyclic chemistry;
li, j. j., ed.; wiley: hoboken,nj, 2005, 465?468. (review).