名称：2-氨基-4-羟甲基噻唑
英文名称：(2-aminothiazol-4-yl)methanol
分子式：c4h6n2os
分子量: 130.17
cas no.：51307-43-8
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
ethanol;
reactants can be synthesized in 1 step.
amgen inc., us2007/173506, a1, (2007) 1-bromo-3-hydroxypropan-2-one (60 g, 392 mmol) and thiourea (34 g, 451 mmol) were charged into a 1 l round bottom flask containing 400 ml of etoh. the resulting mixture was heated to reflux for 90 min utes. the reaction mixture was then cooled and concentrated under reduced pressure, and a precipitate formed. the product was obtained as a solid (40 g, yield=80percent) after filtration and washing t hree times with hexane. the product was used directly in the next step without further purification. lcms (api-es) m/z (percent) 131.2 (100percent, m h).