别名：2-溴-4-噻唑羧酸
英文名称：2-bromo-4-thiazolecarboxylic acid
分子式：c4h2brno2s
cas no.：5198-88-9
分子量：208.03
结构式：
规格：95%
外观：黄色固体
用途：基础原料、有机中间体、医药中间体
合成路线如下：
lithium hydroxide; tetrahydrofuran;
reactants are commercially availlable.
ignar, diane michele, us2010/113512, a1, (2010) step 1: 2-bromo-1,3-thiazole-4-carboxylic acid a mixture of methyl 2-bromo-1,3-thiazole-4-carboxylat e (4.2 g, 18.9 mmol), thf (120 ml) and 1n lithium hydroxide (50 ml) was heated at 70°c. for 1 h. th e organic solvent was removed in vacuo. the residual aqueous solution was cooled to 0-5°c. and acid ified to ph1 with 1n hcl solution. the tile compound was obtained by filtration, as a white solid. 1 h nmr (400 mhz, dmso-d6) delta ppm 8.43 (s, 1h) 13.30 (s, 1h).