别名：3,3-二氟哌啶盐酸盐
英文名称：3,3-difluoropiperidine hydrochloride
分子式：c5h10clf2n
cas no.：496807-97-7
分子量：157.59
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
hydrogenchloride; hydrogen; methanol; ethanol; palladium on carbon catalyst
reactants can be synthesized in 1 step.
novartis pharma gmbh, wo2004/69256, a1, (2004) to a solution of 1-benzyl-piperidin-3-one (1g) in ch2ci2 (loml) is added [bis (2-methoxy- ethyl) amino] sulfer trifluoride (1. 84ml) at 0c, and stirred for 1.5hr at room temperature. the reaction mixt ure is poured in aqueous nahc03 and extracted with ethyl acetate. the organic layer is successively washed with h20 and aqueous naci, dried over mgs04, and concentrated in vacuo. the residue is purifi ed by column chromatography to give a colorless oil. the oil and pd/c (5percent w/w on activated carbon, 100mg) in hci in etoh/meoh (50ml) is stirred for 22hr under h2 atmosphere. the reaction mixture is filtrated through celite pad. 4the filtrate is added hci in etoac, then concentrated in vacuo to provide the title compound.